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组织因子—一种乳腺癌潜在的治疗和诊断的标靶
科研动态 2013-08-05 15:45 已被浏览 3224 次
组织因子—一种乳腺癌潜在的治疗和诊断的标靶
Tissue factor, a potential biomark for breast cancer diagonise and gene therapy
联系人：李超副教授，电子邮件：cli12 @ mail点xjtu点edu点cn
Contact: Associate Professor Chao Lii, Email:cli12 @ mail dot xjtu dot edu dot cn
通过对组织因子胞浆内部分参与信号传导进行较系统和深入的研究，着重研究组织因子-蛋白酶激活受体2信号通路，通过p38MAPK对于雌激素受体的表达产生的影响,以及组织因子通过对于雌激素受体表达的调控，对于乳腺癌增生、侵袭、血管再生等方面体内和体外的影响。研究结果能使人们更好的认识和理解信号传导对于乳腺癌发展过程所产生的影响，具有重要学术价值。同时，组织因子作为跨膜蛋白，其胞浆内部分直接参与乳腺癌增生、侵袭和血管再生的信号通路，可以做为潜在的肿瘤治疗靶向，其对于雌激素受体的调控，可以为内分泌激素治疗提供帮助，具有重要的癌症治疗应用前景。
This project is going to investigate the influence of cytoplasm domain of tissue factor (TF) to the cellular signaling, especially TF can regulate estrogen receptor alpha (ERa) expression through the activation of signal transduction pathways via protease active receptor 2(PAR2) and p38MAPK. Also this project is going to investigate the influence of TF to breast cancer growth, angiogenesis and invasion by regulate the ER expression. The results will contribute to better understand for the influence of cellular signaling to the breast cancer progress, therefore, TF may be recognized as potential tumour target therapy and contribute to the breast cancer endocrine therapy by the regulation of ERa expression.
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